Can I Take Antidepressants During Pregnancy?

Wondering if antidepressants are safe in pregnancy? Learn the risks of untreated depression, what research shows, and how Lunea’s perinatal psychiatrists can support you.

Why This Question Matters

Pregnancy can be both joyful and emotionally challenging. Many women worry about whether continuing or starting antidepressants could harm their baby. The reality is that both untreated depression and medication use carry risks — the key is balancing them with professional support.

Risks of Untreated Depression

Stopping antidepressants suddenly can lead to relapse. A landmark study by Cohen et al. (2006) found relapse rates of 60–70% in women who discontinued their medication during pregnancy. Untreated depression is linked to:

• Poor sleep and nutrition

• Increased substance use

• Preterm birth and low birth weight

• Higher risk of postpartum depression

• Difficulty bonding with your baby

👉 Learn about recognising postpartum depression in our blog

Are Antidepressants Safe in Pregnancy?

The most commonly used medications are SSRIs (selective serotonin reuptake inhibitors).

• Large studies show they are generally safe.

• Small risks exist, such as neonatal adaptation syndrome (usually mild and temporary).

• Rare associations with a condition called pulmonary hypertension of the newborn and case reports of congenital anomalies have been reported, but the absolute risks remain low.

How Decisions Are Made

Every woman’s situation is unique. Decisions depend on:

• History of depression or anxiety

• What medications you’ve responded to before

• Severity of current symptoms

• Support systems in place and personal preferences

A perinatal psychiatrist can weigh risks and benefits for your individual case.

Non-Medication Options

For some women, therapy and lifestyle strategies may be effective on their own, or alongside medication:

• Psychological therapies such as CBT or IPT

• Mindfulness and stress-reduction techniques

• Exercise, sleep hygiene, and nutrition

• Support groups or peer networks

How Lunea Can Help

At Lunea, we specialise in perinatal psychiatry — care for women during pregnancy and postpartum. Our psychiatrists:

• Help weigh up the risks and benefits of antidepressants

• Provide coordinated care with your GP and obstetric team

• Offer telepsychiatry across Australia

• Ensure short wait times so you get support when you need it

👉 Book an appointment with a Lunea psychiatrist

References & Resources

- Cohen LS et al. (2006). Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment. JAMA.

- Beyond Blue – Pregnancy and Mental Health: https://www.beyondblue.org.au